Motor oil exposure and arthritis risk link
Occupational spray to granite grease, within being finicky
hydraulic or motor oil, upsurge the destiny of embryonic rheumatoid
arthritis beside 30%. These be the grades of a exploration
published today in Arthritis Research & Therapy.
Berit Sverdrup and Lars Alfredsson, from the Karolinska
Institutet in Stockhom, Sweden, and colleagues select a elite of
patients diagnose with rheumatoid arthritis (RA) concerning May
1996 and December 2003. They matched these patients with bunting
city of indistinguishable age, femininity and residential crumb,
who acted by means of controls. Shortly after they enjoy be
diagnosed with RA, the patients be ask to wide-ranging a
questionnaire concerning work exposure to differing form of
mineral oils, such as quotation oil, motor oil, sort oil,
hydraulic oil and asphalt. The same questionnaire be send to
controls.
In entire, the study built-in 1419 cases and 1674 controls. Only
man report large occupational exposure to oil, chiefly motor and
hydraulic oil. A group of 135 men diagnosed with RA and packet
journalism high exposure, as okay as 132 tuneful controls, was
retained in choose of further study.
Sverdrup et al.’s results attest that men a tremendous operation
exposed to motor or hydraulic oil have a 30% stately risk of
developing RA than unexposed men. Exposure solely increased the
risk of developing ‘rheumatoid factor positive’ (RF) rheumatoid
arthritis, a more ascetic form of RA. It didn’t increase the risk
of developing rheumatoid factor gloomy (RF-) rheumatoid
arthritis. Exposure to oil be also linked to a 60% increased risk
of developing ‘anti-citrulline positive’ (anti-CP) rheumatoid
arthritis, another type of the illness.
This study confirm results found in animals - exposure to mineral
oil had been shown to homily into arthritis in rats - and put
against a pedestal question regarding exposure to other
biological or occupational agents, such as effortlessly spread
agents that focus molecules that may initiate the immune set of
laws in as moral as ways as mineral oils, and a practicable fix
together with arthritis.
Article: Association between occupasional exposure to mineral oil
and rheumatoid arthritis. Results from the Swedish EIRA
case-control study Berit Sverdrup, Henrik, Camilla Bengtsson,
Ingvar Lundberg, Leonid Padyukov, Lars Alfredsson, Lars
Klareskog, and the EIRA study group Arthritis Research &
Therapy 2005, 7:R1296-R1303 (23 September 2005) Juliette Savin
juliette.savin@biomedcentral.com 44-207-631-9931 BioMed Central
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